Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

This paper accepts as given that business students want to get ahead. It criticizes business schools for their failure to reduce the incongruence between doing what is right and doing what it takes to get ahead. Because of this failure business school graduates carry negative ideas, attitudes and behaviors vis-à-vis social responsibility from business schools into the business world. Recommendations are made for increasing the social responsibility of business schools.

Menzius war ein prominenter politischer Denker des antiken China und ein hochrangiger Berater des mächtigen Fürsten von Qí. Im Werk Mèngzi “Junker Mèng” sind Dialoge zu politischen Fragen überliefert, die er mit wichtigen Fürsten, mit seinen Gefolgsleuten und mit Gegnern führte. Angesichts des Niedergangs der Zhou-Könige sind Fragen der Herrschaftsform sowie der adäquaten Verwaltung zentral. Dabei behandelte er anthropologische Aspekte der geistigen Konstitution der Menschen und verteidigte so die traditionelle verwandtschaftliche und gesellschaftliche Organisation und ihre Werte. Das Werk bietet eine (...) neue Rekonstruktion der Biographie und der Zeit des Menzius, eine darauf fussende Übersetzung in neuer Anordnung mit detaillierten Kommentaren sowie umfangreiche Anhänge zu Chronologie, Geschichte, Personen und zentralen Begriffen. Es richtet sich an ein sinologisches Fachpublikum und an ideengeschichtlich Interessierte. (shrink)

The paper outlines the policy context and summarizes the numerous policy issues that AD raises from the more generic to the unique. It posits that strong public fears of AD and its future prevalence projections and costs, raise increasingly difficult policy dilemmas. After reviewing the costs in human lives and money and discussing the latest U.S. policy initiatives, the paper presents two policy areas as examples the demanding policy decisions we face. The first focuses on the basic regulatory function of (...) protecting the public from those who would exploit these fears. The second centers on the well-debated issues of advance directives and euthanasia that surround AD. Although more dialogue, education and research funding are needed to best serve the interests of AD patients and families as well as society at large, this will be challenging because of the strong feelings and divisions AD engenders. (shrink)

Glenberg focuses on conceptualizations that change from moment to moment, yet he dismisses the concept of working memory (sect. 4.3), which offers an account of temporary storage and on-line cognition. This commentary questions whether Glenberg's account adequately caters for observations of consistent data patterns in temporary storage of verbal and visuospatial information in healthy adults and in brain-damaged patients with deficits in temporary retention.

Children’s early science interest begins well before middle school, and parents can be important in generating and sustaining such interest. This qualitative study addresses how parental occupations shape physical scientists’ early science interest. Our framework uses Social Cognitive Career Theory, and our research question is, “How do parental occupations create learning opportunities for children and motivate them to pursue physical science?” We examine interviews from 17 physical scientists in Project Crossover, a sequential mixed-methods study that broadly examines factors influencing entry (...) into physics and chemistry doctoral programs. Parental occupations can create learning opportunities through role modeling, encouragement, exposure, familiarity, and bonding. Thus, parents can be valuable in creating learning opportunities for children outside classrooms. Study limitations include a small sample and lack of information about familial structure. Our research contributes to the emergent understanding of the role of parental occupations in science interest, which further influences individual career trajectories. (shrink)

The centerpiece of Aldous Huxley's Brave New World is state control of the human reproduction process as a means of ensuring social stability. Although written as fiction, recent advances in human genetic and reproductive technology promise to give us more control over our biological destiny, including procreation. Concurrently, they create new social policy dilemmas, challenge prevailing "givens" of the human condition, and, technologically, increase the possibility of centralized control over reproduction. After reviewing the current status of human genetic technology and (...) discussing its use in the United States, this article analyzes the implications of these innovations for the future. (shrink)

One of the arguments that has been directed against the Buddhist anātman (“non-self”) theory, by Dan Zahavi among others, is that the doctrine cannot account for why we never mistake our own bodies for the bodies of others. This is not, however, a new objection; it can be found, for example, in a list of objections to the anātman doctrine in the Dazhidulun (“Treatise on the Great Perfection of Wisdom”), a medieval compendium attributed to Nāgārjuna and compiled and translated (and (...) perhaps partially authored) by Kumārajīva in the early fifth century. The text offers several responses to this objection, the most interesting of which is the claim that there is indeed an instance of a person experiencing himself as another. We then hear the tale of a young man who went through a “body transplant”—his body is replaced, piece by piece, with that of a corpse. In my chapter, I analyze this amusing but nonetheless illuminating narrative, showing how the story is a classic example of a medieval Buddhist “thought experiment” (Gedankenspiel), which was freely altered by Buddhist authors as it was deployed in different doctrinal/philosophical contexts. I conclude with some reflections on how our approach to such didactic tales affects our understanding and appreciation of Buddhist philosophy writ large. (shrink)

Tocqueville pessimistically predicted that liberty and equality would be incompatible ideas. Robert Dahl, author of the classic _A Preface to Democratic Theory,_ explores this alleged conflict, particularly in modern American society where differences in ownership and control of corporate enterprises create inequalities in resources among Americans that in turn generate inequality among them as citizens. Arguing that Americans have misconceived the relation between democracy, private property, and the economic order, the author contends that we can achieve a society of (...) real democracy and political equality without sacrificing liberty by extending democratic principles into the economic order. Although enterprise control by workers violates many conventional political and ideological assumptions of corporate capitalism as well as of state socialism. Dahl presents an empirically informed and philosophically acute defense of "workplace democracy." He argues, in the light of experiences here and abroad, that an economic system of worker-owned and worker-controlled enterprises could provide a much better foundation for democracy, political equality, and liberty than does our present system of corporate capitalism. (shrink)

And I find myself knowing the things that I knew Which is all that you can know on this side of the blueIs there such a thing as direct, non-conceptual experience, or is all experience, by its very nature, conceptually mediated? Is some notion of non-conceptual sensory awareness required to account for our ability to represent and negotiate our physical environment, or is it merely an artifact of deep-seated but ultimately misguided Cartesian metaphysical assumptions? Perhaps conscious experience in humans is (...) inextricably tied to the representational or self-reflexive capacities of language; if so, does it necessarily follow that newborn infants and animals are not conscious? Is the very notion of non-conceptual... (shrink)

A popular three-stage argument appraisal strategy calls for (1) identifying the parts of the argument, (2) classifYing the argument as deductive, inductive, or some other type, and (3) appraising the argument using the standards appropriate for the type. This strategy fails for a number of reasons. I propose a comprehensive alternative approach that distinguishes between inductive, deductive, and other standards; calls for the successive application of standards combined with assumption-ascription, according to policies that depend for their selection on the goals (...) of the appraiser; and provides for qualified reasoning. (shrink)

Necessary-condition analyses of singular causal claims are particularly vulnerable to cases of linked overdetermination, so named because the nonoperation of the back-up factor (in fail-safe cases) or the preempted factor (in preemptive cases) is linked to the operation of the actual cause. As an example J. L. Mackie's analysis is here challenged with a simple switch-light case. Three replies are considered, a facts-vs.-events reply, a different-effect reply, and an in-the-circumstances reply. All are found deficient.

SummaryIn this essay I offer a set of characteristic scientific activities, accompanied by principles to be used as guides in performing these activities, and dispositions that are desirable for the person performing these activities to have. This set is intended to provide a rough and ready elaboration of scientific thinking as a goal for our schools and colleges.Although they are here labeled scientific, they are intended to apply to other activities than doing what is standardly called science. This wider application (...) is part of the justification for offering science in our schools and colleges. We want people to think scientifically about many other aspects of their lives, as well as about science content.There is no suggestion that science content is not important, nor that scientific thinking should be taught apart from science content. In fact I think that a very good way to teach scientific thinking is by infusing such instruction in the instruction of science content. See Swartz for a discussion of infusion, and Ennis, for treatments of the subject‐specificity issue that is generally raised when thinking and content are discussed.This essay contains one brief case study that exemplifies most of the activities, principles, and dispositions suggested as goals for the schools. I realize that the validity and comprehensiveness of these goals has not been here demonstrated. The scientists, science educators, philosophers of science, and critical thinking specialists to whom1 have shown them are in general agreement about them, but the ultimate test will be in whether the goals are widely adopted and successfully serve as guidance in the promotion of scientific thinking.I hope that this elaboration of scientific thinking and its formulation in terms of a suggested set of goals are “dear and precise as is needed in the situation”. (shrink)

Vulnerabilities often characterize the availability of immigrant populations of interest in social behavioral science, public health, and medical research. Refugees, asylum seekers, and undocumented immigrants present unique vulnerabilities relevant to protocol development as well as ethics review procedures and criteria. This paper describes vulnerable populations in relation to the Belmont Report and US federal regulations for the protection of human subjects, both of which are commonly used in international research contexts. It argues for safeguards for immigrants comparable to protections for (...) such populations as pregnant women, prisoners, and children. The paper further presents a two-part model for the review of protocols that involve immigrants. The model is intended to help identify the risks to immigrants associated with participation in research, and to suggest how researchers can responsibly frame studies and access to research participant immigrants through community-based, and/or non-governmental organizations that serve immigrants and immigrant communities. (shrink)

Rapid advances in biomedicine, accompanied by changing social values, are thrusting bioethical decision making into the political spectrum. This article examines the forces which are politicizing bioethical decisions and demonstrates the challenges they raise. It also presents an overview of the current political context and concludes that American political institutions and processes are not well-suited for dealing with these intense, sensitive bioethical issues. Although the article reflects skepticism concerning the ability of the political system to fulfill the expansive demands confronting (...) it, it ends by suggesting several potential adaptations which should make the process more responsive and the institution's actions more effectual. (shrink)

A vision of law and justice that is rooted in relationality stands at the heart of this paper. To tribal people, such as the Lakota and Dakota, what sustains the lives of people are bonds of kinship relations that bind human and nonhuman life together with a sense of mutual responsibility and caring that is most aptly captured by the Lakota phrase Mitakuye Oysain, "all are relatives." What are important to tribal communities are collective rights and obligations as embodied in (...) Indian law and justice. Indian societies, thereby, have established their own tribal courts and legal systems that are markedly different from mainstream society. Indian people, it is argued, have much to teach about the limitations of the dominant legal culture and ways in which relationality serves a far better basis for law and justice than an adversarial system that demands winners and losers. (shrink)

Existing research has examined if undergraduate factors influence chemistry and physics, or physical science, doctoral degree entry and whether variables during PhD programs associate with graduation. Yet research on the transition from bachelor’s degree to doctoral degree entry (i.e., PhD entry in less than 6 months, attainment of a master’s degree prior to doctoral degree entry, or working in a science-related job for more than a year prior to doctoral degree entry) on PhD degree graduation remains scarce. Our study examines (...) the transition from bachelor’s to doctoral degrees to see if experiences therein associate with female PhD graduation, after doctoral degree enrollment. Our logistic regression analysis, of female chemistry and physics doctorates (n = 867), indicated that attainment of a master’s degree did not change the likelihood of graduation, when compared to direct entry into physical science doctoral programs. Meanwhile working in a science-related job for a year or more is associated with a significantly lower likelihood of physical science doctoral graduation when compared to women who entered directly into PhD programs or received a master’s degree prior to enrollment. (shrink)

In this book, I make use of an idea from economics to suggest how noble human tendencies might not only have survived the ruthless pressures of the material world, but actually have been nurtured by them.

While indeterminacy is a recurrent theme in philosophy, less progress has been made in clarifying its significance for various philosophical and interdisciplinary contexts. This collection brings together early-career and well-known philosophers--including Graham Priest, Trish Glazebrook, Steven Crowell, Robert Neville, Todd May, and William Desmond--to explore indeterminacy in greater detail. The volume is unique in that its essays demonstrate the positive significance of indeterminacy, insofar as indeterminacy opens up new fields of discourse and illuminates neglected aspects of various concepts and (...) phenomena. The essays are organized thematically around indeterminacy's impact on various areas of philosophy, including post-Kantian idealism, phenomenology, ethics, hermeneutics, aesthetics, and East Asian philosophy. They also take an interdisciplinary approach by elaborating the conceptual connections between indeterminacy and literature, music, religion, and science. (shrink)

Leist worries that by tying the ideal of cooperation to the aim of promoting the good I exhibit a bias towards consequentialism, and that this in turn leads me to downsize the role to be played by the ideal of cooperation within moral theory. I maintain that no bias is exhibited towards consequentialism but acknowledge that realism is being favoured over constructivism. I further argue that the role assigned to the ideal of cooperation is as large as realism permits.

In the United States of America, the years from 1880 to 1915 were a period of rapid urbanization, combined in some areas with intense industrialization. This paper explores the creation in cities of the new industrial heartland of new institutions of higher learning. The case studies chosen illustrate varying responses to local needs for scientific and technical expertise, and illuminate how new concepts of higher education in the United States helped to shape the emergent connection between science and industry.

The results of a hypothetical experiment requiring a sequence of quantum measurements are obtained retrospectively, after the experiment has been completed, from a single reading of an “apparatus register.” The experiment is carried out reversibly and Schrödinger's equation is satisfied until the terminal reading of the register. The technique is illustrated using a feasible method of measuring photon spin as the quantum “object” observable and using the photon energy as the “apparatus register.” The technique is used to discuss the “watchdog” (...) effect, the effect of repeated measurements inhibiting quantum jumps. (shrink)

Glorification of students, neo-utilitarianism, secular humanism, and a crisis in confidence have all contributed to the declining influence of Catholicism on the Catholic campus.